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God mode: Start Abuse with the -edit command line option. Then while playing, press Shift-Z. Then press TAB to turn on God mode.
Full health: Save your game while at a console and then restore your game. This will give you 100% health. (Will not work on the extreme difficulty)
Abuse Game Review courtesy of DOSGames.com:
Abuse is a great side-scrolling action game that uses a unique system to control your character. You use the keyboard to move around and the mouse to aim your gun. It works pretty well and the game can be great fun to play, since it has nicely done graphics and sound effects, as well as many levels and powerups. ("Free Abuse" is a fan project to remake the original Abuse game using public domain material. In practical terms it should be the same as the original game.)